Published Science Writing

Peer-Reviewed Journal Articles and Book Chapters

• Cox, G. W., Orosz, C.G. and Fertel, R.H.:  8-Methoxypsoralen inhibits lymphocyte proliferation in vitro in the absence of ultraviolet radiation.  International Journal of Immunopharmacology 9:475-481, 1987.
• Cox, G.W., Orosz, C.G., Lewis, M.G., Olsen, R.G. and Fertel, R.H.:  Evidence that 8-methoxypsoralen (8-MOP) is a T-lymphocyte immunomodulatory agent.  International Journal of Immunopharmacology 10:773-781, 1988.
• Cox, G.W., Mathieson, B.J., Gandino, L., Blasi, E., Radzioch, D. and Varesio, L.:  Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver.  Journal of the National Cancer Institute 81:1492-1496, 1989.
• Pierce, J.H., DiMarco, E., Cox, G.W., Lombardi, D., Ruggiero, M., Varesio, L., Wang, L.M., Choudhury, G.G., Sakaguchi, A.Y., DiFiore, P.P. and Aaronson, S.A.:  Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.  Proceedings of the National Academy of Sciences U.S.A. 87:5613-5617, 1990.
• Cox, G.W., Mathieson, B.J., Giardina, S.L., and Varesio, L.:  Characterization of IL-2 receptor expression and function on murine macrophages.  The Journal of Immunology 145:1719-1726, 1990.
• Cox, G.W., Espinoza-Delgado, I., Longo, D.L., and Varesio, L.: Expression and function of interleukin-2 receptors on human monocytes and murine macrophages.  In:  Cellular and Cytokine Networks in Tissue Immunity, M. Meltzer and A. Mantovani, eds., Wiley-Liss, New York, 1991, pp. 301-306.
• Cox, G.W., Chattopadhyay, U., Oppenheim, J.J., and Varesio, L.:  IL-4 inhibits the costimulatory activity of IL-2 or picolinic acid but not of lipopolysaccharide on IFN-γ-treated macrophages.  The Journal of Immunology 147:3809-3814, 1991.
• Varesio, L., Cox, G.W., Pulkki, K., Brooks, A. and Melillo, G.:  Arginine and tryptophan catabolism:  the picolinic acid connection.  In:  Advances in Tryptophan Research, I. Ishiguro, R. Kido, T. Nagatsu, Y. Nagamura, and Y. Otha, eds., Fujita Health University Press, Toyoake, Japan,  1992, pp. 309-314.
• Cox, G.W., Melillo, G., Chattopadhyay, U., Mullet, D., Fertel, R.H. and Varesio, L.:  Tumor necrosis factor-α-dependent production of reactive nitrogen intermediates mediates IFN-γ plus IL-2-induced murine macrophage tumoricidal activity.  The Journal of Immunology 149:3290-3296, 1992.
• Varesio, L., Cox, G.W., Pulkki, K., Musso, T., Latham, P.S., Gusella, G. L. and Espinoza-Delgado, I.:  Activation of macrophages and monocytes by interferon-γ and IL-2. In:  Mononuclear Phagocytes in Cell Biology, G. Lopez-Berestein and Klostergaard, J., eds.: Boca Raton, CRC Press, Inc., 1993, pp. 119-146.
• Melillo, G., Cox, G.W., Radzioch, D. and Varesio, L.:  Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages.  The Journal of Immunology 150:4031-4040, 1993.
• Melillo, G., Cox, G.W., Biragyn, A., Sheffler, L.A., and Varesio, L.:  Regulation of nitric-oxide synthase mRNA expression by interferon-γ and picolinic acid.  Journal of Biological Chemistry 269:8128-8133, 1994.
• Wang, M.-H., Cox, G.W., Yoshimura, T., Sheffler, L.A., Skeel, A. and Leonard, E.J.:  Macrophage-stimulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages.  Journal of Biological Chemistry 269:14027-14031, 1994.
• Musso, T., Bosco, M.C., Longo, D.L., Espinoza-Delgado, I., Sica, A., Cox, G.W., Gusella, G.L., Forni, G. and Varesio, L.:  LPS-inducible nuclear factor in human monocytes that binds the negative regulatory element of the HIV LTR.  Journal of Leukocyte Biology 56:21-26, 1994.
• Wink, D.A., Nims, R.W., Darbyshire, J.F., Christodoulou, D., Hanbauer, I., Cox, G.W., Laval, F., Laval, J., Cook, J.A., Krishna, M.C., DeGraff, W.G. and Mitchell, J.B.:  Reaction kinetics for nitrosation of cysteine and glutathione in aerobic nitric oxide solutions at neutral pH.  Insights into the fate and physiological effects of intermediates generated in the NO/O2 reaction.  Chemical Research and Toxicology 7:519-525, 1994.
• Cox, G.W.:  Assay for macrophage-mediated anti-tumor cytotoxicity.  In:  Current Protocols in Immunology, J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach and W. Strober, eds., John Wiley & Sons, Inc., New York, 1994, pp. 14.7.1-14.7.10.
• Hanbauer, I., Cox, G.W., and Wink, D.A.:  Synaptic and extrasynaptic action of free radicals on cell-to-cell signaling.  Annals of the New York Academy of Sciences 738:173-180, 1994.
• Blasi, E., Puliti, M., Pitzurra, L., Barluzzi, R., Mazzolla, R., Adami, C., Cox, G.W. and Bistoni, F.:  Comparative studies on functional and secretory properties of macrophage cell lines derived from different anatomical sites.  FEMS Immunology and Medical Microbiology 9:207-215, 1994.
• Varesio, L., Espinoza-Delgado, I., Gusella, L., Cox, G.W., Melillo, G., Musso, T. and Bosco, M.C.:  Role of cytokines in the activation of monocytes.  In:  Human Cytokines: Their Role in Disease and Therapy, B.B. Aggarwal and R.K. Puri, eds., Blackwell Science, Inc., Cambridge, 1995, pp. 55-70.
• Sheffler, L.A., Wink, D.A., Melillo, G. and Cox, G.W.:  Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. Journal of Leukocyte Biology 57:152-159, 1995.
• Nims, R.W., Darbyshire, J.F., Saavedra, J.E., Christodoulou, D., Hanbauer, I., Cox, G.W., Grisham, M.B., Laval, J., Cook, J.A., Krishna, M.C. and Wink, D.A.:  Colorimetric methods for the determination of nitric oxide concentration in neutral solutions.  Methods, A Companion to Methods in Enzymology 7:48-54, 1995.
• Sheffler, L.A., Wink, D.A., Melillo, G. and Cox, G.W.:  Exogenous nitric oxide regulates IFN-γ plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages.  The Journal of Immunology 155:886-894, 1995.
• Taub, D.D., and Cox, G.W.:  Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production.  Journal of Leukocyte Biology 58:80-89, 1995.
• Melillo, G., Musso, T., Sica, A., Taylor, L.S., Cox, G.W. and Varesio, L.:  A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.  Journal of Experimental Medicine 182:1683-1693, 1996.
• Wigginton, J.M., Kuhns, D.B., Back, T.C., Brunda, M.J., Wiltrout, R.H. and Cox, G.W.:  Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice:  Implications for the antitumor activity of interleukin 12 and/or interleukin 2.  Cancer Research 56:1131-1136, 1996.
• Schwabe, M., Cox, G.W., Bosco, M.C., Prohaska, R. and Kung, H.-F.:  Multiple cytokines inhibit interleukin-6-dependent murine hybridoma /plasmacytoma proliferation.  Cellular Immunology 168:117-121, 1996.
• Melillo, G., Taylor, L.S., Brooks, A., Cox, G.W. and Varesio, L.:  Expression and regulation of inducible nitric oxide synthase in interferon-γ-treated murine macrophages cultured under hypoxic conditions.  The Journal of Immunology 157:2638-2644, 1996.
• Cox, G.W., Taylor, L.S., Willis, J.D., Melillo, G., White, R.L., Anderson, S.K. and Lin, J.-J.:  Molecular cloning and characterization of a novel mouse macrophage gene that encodes a nuclear protein comprising polyglutamine repeats and interspersing histidines.  Journal of Biological Chemistry 271:25515-25523, 1996.
• Wigginton, J.M., Komschlies, K.L., Green, J.E., Cox, G.W., Jorcyk, C.L., Back, T.C., Franco, J.L., Brunda, M.J. and Wiltrout, R.H.:  Evaluation of the antitumor activity of the interleukin-12/pulse interleukin-2 combination.  Annals of the New York Academy of Sciences 795:434-439, 1996.
• Mullet, D., Fertel, R.H., Kniss, D. and Cox, G.W.:  An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-γ-treated macrophages.  The Journal of Immunology 158:897-904, 1997.
• Melillo, G., Taylor, L.S., Brooks, A., Musso, T., Cox, G.W. and Varesio, L.:  Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine.  Journal of Biological Chemistry 272:12236-12243, 1997.
• Taylor, L.S., Cox, G.W., Melillo, G., Bosco, M.C., and Espinoza-Delgado, I.:  Bryostatin-1 and IFN-γ synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages.  Cancer Research 57:2468-2473, 1997.
• Duhe, R.J., Evans, G.A., Erwin, R.A., Kirken, R.A., Cox, G.W., and Farrar, W.L.:  Nitric oxide and thiol redox regulation of Janus kinase activity.  Proceedings of the National Academy of Sciences U.S.A. 95:126-131, 1998.
• Chong, H., Vodovotz, Y., Cox, G.W., and Barcellos-Hoff, M.H.:  Immunocytochemical localization of latent transforming growth factor-β1 activation by stimulated macrophages.  Journal of Cell Physiology 178:275-283, 1999.
• Vodovotz, Y., Chesler, L., Chong, H., Kim, S.-J., Simpson, J.T., Degraff, W., Cox, G.W., Roberts, A.B., Wink, D.A., and Barcellos-Hoff, M.H.:  Regulation of transforming growth factor-β1 by nitric oxide.  Cancer Research 59:2142-2149, 1999.
• Clemons-Miller, A.R., Cox, G.W., Suttles, J., and Stout, R.D.:  LPS stimulation of TNF-receptor deficient macrophages: a differential role for TNF-alpha autocrine signaling in the induction of cytokine and nitric oxide production.  Immunobiology 202:477-492, 2000.

Abstracts

• Stege, T.E., Mischke, S., Cox, G.W., and Reider, C.R.:  The role of free-radical inhibitors on acetaldehyde-induced increases in lipid peroxidation.  Ohio Journal of Science 82:40, 1982.
• Stege, T.E., Mischke, B.S., Cox, G.W., and Daniels, K.A.:  The role of free-radical inhibitors on acetaldehyde-induced increases in lipid peroxidation.  Federation Proceedings 42:1296, 1983.
• Cox, G.W. and Fertel, R.H.:  The effect of 8-methoxypsoralen on lymphocyte proliferation.  The Pharmacologist 27:915, 1985.
• Cox, G.W. and Fertel, R.H.:  8-Methoxypsoralen induces immunosuppression and hyporesponsiveness to interleukin-2.  Federation Proceedings 45:1026, 1986.
• Cox, G.W. and Fertel, R.H.:  8-Methoxypsoralen inhibition of T lymphocyte proliferation:  A possible mechanism involving elevated cyclic AMP.  The Pharmacologist 28:547, 1986.
• Fertel, R.H. and Cox, G.W.:  Elevation of cyclic AMP by 8-methoxypsoralen (8-MOP) inhibits lymphocyte proliferation in vitro.  Proceedings of the Xth International Congress of Pharmacology 1987.
• Cox, G.W., Mathieson, B.J., and Varesio, L.:  Immortalized macrophage cell lines express functional interleukin-2 receptors.  FASEB Journal 2:2250, 1988.
• Gusella, G.L., Cox, G.W., Radzioch, D., and Varesio, L.:  Control of c-fms proto-oncogene expression in macrophage cell lines.  FASEB Journal 2:2251, 1988.
• Cox, G.W., Giardina, S.L., Mathieson, B.J., and Varesio, L.:  Interleukin-2 and its receptor are both expressed in an immortalized murine macrophage cell line.  FASEB Journal 3:3465, 1989.
• Pierce, J.H., Cox, G.W., DiMarco, E., DiFiore, P.P., Lombardi, D., Anklesaria, P., Varesio, L., Sachaguchi, A., and Aaronson, S.A.:  CSF-1 induces monocytic differentiation and chemotaxis of IL-3 dependent cells transfected with the human CSF-1 receptor.  Journal of Cellular Biochemistry Supplement 14B: F239, 1990.
• Cox, G.W., Mathieson, B.J., and Varesio, L.:  Characterization of interleukin-2 receptor expression and function on murine macrophages.  Lymphokine Research 9: 4.21, 1990.
• Varesio, L., Latham, P., Gusella, L., Musso, T., Cox, G.W., Espinoza, I., and Longo, D.L.:  Monocyte/macrophage activation: The interleukin-2 (IL 2) and the interferon-gamma (IFNγ) pathways.  Journal of Leukocyte Biology Supplement1:245, 1990.
• Cox, G.W., Chattopadhyay, U., Oppenheim, J.J. and Varesio, L.: Interleukin-4 selectively inhibits interleukin-2-induced murine macrophage cell line tumoricidal activity.  FASEB Journal 5:5679, 1991.
• Latham, P.S., Cox, G.W., Pilaro, A.M. and Varesio, L.:  Interleukin 2 (IL2) induces tumoricidal activity in rat Kupffer cells that express constitutive IL2 receptor (IL2r).  Journal of Cellular Biochemistry Supplement 15F:P235, 1991.
• Melillo, G., Cox, G.W., Wang, J.M. and Varesio, L.:  Interleukin-2 augments JE mRNA expression and chemotactic activity in mouse macrophages.  FASEB Journal 6:4535, 1992.
• Cox, G.W., Mullet, D., Fertel, R.H. and Varesio, L.:  L-arginine mediates the interleukin-2-dependent tumoricidal activity of mouse macrophages.  FASEB Journal 6:4527, 1992.
• Radzioch, D., Melillo, G., Hel, Z., Cox, G.W., Barrera, L., Boule, M., Skamene, E. and Varesio, L.:  Regulation of TNFα expression by IFN γ and picolinic acid in macrophages activated for tumoricidal functions.  8th International Congress of Immunology 44-32, 1992.
• Melillo, G., Cox, G.W., Biragyn, A., Sheffler, L.A., and Varesio, L.:  Picolinic acid and interferon-γ synergistically induce nitric oxide synthase mRNA expression in murine macrophages.  The Journal of Immunology 150 (8 Pt. II):296, 1993.
• Cox, G.W., Sheffler, L.A., Wink, D.A., and Melillo, G.:  Nitric oxide-releasing compounds augment the activity of an ADP-ribosyltransferase in murine macrophages.  The Journal of Immunology 150(8 Pt. II):294, 1993.
• Melillo, G., Musso, T., Cox, G.W., and Varesio, L.:  Multiple regions of the nitric oxide synthase (NOS) promoter mediate interferon-gamma (IFN-γ) plus picolinic acid induction of NOS transcription in murine macrophages.  FASEB Journal 8:1209, 1994.
• Cox, G.W., Melillo, G., Sheffler, L.A., Willis, J.D., and Varesio, L.:  Inhibition of proliferation of immortalized mouse macrophages by cytokines and nitric oxide.  FASEB Journal 8:2954, 1994.
• Mullet, D., Cox, G.W., and Fertel, R.H.:  cAMP Modulates the production of nitric oxide by IFN-γ treated ANA-1 macrophages.  Proceedings of the XIIth International Congress of Pharmacology 1994.
• Melillo, G., Musso, T., Cox, G.W., Sica, A., Sheffler, L.A., and Varesio, L.:  Identification of a functional picolinic acid-response element in the promoter of inducible nitric oxide synthase (iNOS) gene.  FASEB Journal 9:4510, 1995.
• Sheffler, L.A., Wink, D.A., Melillo, G., and Cox, G.W.:  Exogenous nitric oxide (NO) regulates interferon-γ plus lipopolysaccharide-induced NO synthase expression in mouse macrophages.  FASEB Journal 9:6019, 1995.
• Mullet, D., Bian, X., Cox, G.W., Zaveri, N., Gerber, N., and Fertel, R. H.:  Gallium nitrate inhibits nitric oxide production by activated ANA-1 macrophages.  FASEB Journal 9:5481, 1995.
• Zaveri, N., Mullet, D., Cox, G.W., and Fertel, R.:  Modulation of nitric oxide production in murine macrophages by purinergic compounds.  FASEB Journal 9:699, 1995.
• Cox, G.W., Anderson, S.K., Taylor, L.S., Melillo, G., Willis, J.D., and Lin, J.-J.:  Cloning and characterization of a novel mouse macrophage gene that encodes a putative transcription factor.  Journal of Leukocyte Biology Supplement 58:78, 1995.
• Melillo, G., Taylor, L.S., Brooks, A., Cox, G.W., and Varesio, L.:  Regulation of inducible nitric oxide synthase (iNOS) expression in hypoxic conditions.  Proceedings of the American Association for Cancer Research 37:3574, 1996.
• Wigginton, J.M., Kuhns, D.B., Back, T.C., Brunda, M.J., Wiltrout, R.H., and Cox, G.W.:  Interleukin-12 induced production of nitric oxide by macrophages in vivo:  implications for the antitumor activity of the interleukin-12/pulse interleukin-2 regimen.  Proceedings of the American Association for Cancer Research 37:3099, 1996.
• Chesler, L., Cox, G.W., Barcellos-Hoff, M.H., Wolf, J., Takeguchi, H., Roberts, A., Kim, S.-J., and Vodovotz, Y.:  Effects of nitric oxide on the production of transforming growth factor β1 by tumor cells.  Proceedings of the American Association for Cancer Research 37:295, 1996.
• Melillo, G., Taylor, L.A., Brooks, A., Cox, G.W., Varesio, L.:  Cooperative interaction between hypoxia and lipopolysaccharide (LPS) in the activation of the inducible nitric oxide synthase (iNOS) promoter.  The Journal of Immunology
• Cox, G.W., Taylor, L., Back, T., Wigginton, J., and Wiltrout, R.:  Cloning and characterization of the novel cytokine- and lipopolysaccharide-inducible gene GRP-1 (Glutamine Repeat Protein-1).  Gordon Research Conference: Phagocytes, Holderness, NH, June 8-13, 1997.
• Cox, G.W., Taylor, L., Back, T., Wigginton, J., Wiltrout, R., and Gu, C.:  Cloning and characterization of the novel cytokine- and lipopolysaccharide-inducible gene GRP-1.  Keystone Symposia on Molecular and Cellular Biology: Transcriptional Mechanisms (Abst. 213), Taos, NM, February 21-26, 1998.
• Cox, G.W. and Gu, C.:  Molecular cloning and characterization of a unique interferon-gamma- and lipopolysaccharide-inducible nuclear protein expressed in macrophages. Keystone Symposia on Molecular and Cellular Biology: Macrophage Biology (Abst. 410), Keystone, CO, January 22-28, 1999.
• Cox, G.W., Nawaz, Z., and Johnson, G.V.W.:  Analysis of a unique nuclear transglutaminase (TGase) substrate expressed in macrophages.  FASEB Journal 14:191.2, 2000.